Mibefradil alters intracellular calcium concentration by activation of phospholipase C and IP3 receptor function
نویسندگان
چکیده
منابع مشابه
Na/K-ATPase tethers phospholipase C and IP3 receptor into a calcium-regulatory complex.
We have shown that the caveolar Na/K-ATPase transmits ouabain signals via multiple signalplexes. To obtain the information on the composition of such complexes, we separated the Na/K-ATPase from the outer medulla of rat kidney into two different fractions by detergent treatment and density gradient centrifugation. Analysis of the light fraction indicated that both PLC-gamma1 and IP3 receptors (...
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ژورنال
عنوان ژورنال: Molecular Biomedicine
سال: 2021
ISSN: 2662-8651
DOI: 10.1186/s43556-021-00037-0